In the cuttlefish, Sepia officinalis, healing of the arm stump after amputation is characterized by migration of blood cells toward the wound and by massive synthesis of collagen, followed by the spreading of epithelial cells over the wound. The collagen synthesis is temperature dependent. The role of both amoebocytes and the shifting epidermis in the synthesis of collagen is hypothesized. It is concluded that variations in collagen amount may be considered as an indicator of the progress of tissue repair.
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